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Hindi Editorial, J Liver Dis Transplant Vol: 1 Issue: 1
Defining Single Nucleotide Polymorphic (SNP) Variants Role of Human Angiotensinogen in Liver Fibrosis
| Rais A. Ansari* | |
| College of Pharmacy, Nova Southeastern University, Florida, USA | |
| Corresponding author : Rais A Ansari Department of Pharmaceutical Sciences, College of Pharmacy, Health Professions Division, Terry Building, Rm 1344, Nova Southeastern University, 3200 S University Drive, Fort Lauderdale, FL 33328, USA Tel: (954)-262-1344 E-mail: ra557@nova.edu |
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| Received: June 07, 2012 Accepted: June 08, 2012 Published: June 10, 2012 doi:10.4172/2325-9612.1000e101 | |
| Citation: Rais A. Ansari, et al (2012) Defining Single Nucleotide Polymorphic (SNP) Variants Role of Human Angiotensinogen in Liver Fibrosis. J Liver:: Dis Transplant 1:1. doi:10.4172/2325-9612.1000e101 |
Abstract
Defining Single Nucleotide Polymorphic (SNP) Variants Role of Human Angiotensinogen in Liver Fibrosis
The sequencing of human genome has lead to define the variations among individuals, which is quite astonishing. With the advent of single nucleotide variants among genes, that is believed to be present in every 1.0 kb in human genome, determining the effects of these variants on biological process has been a daunting task. Utilizing the modern molecular biological techniques, the role(s) of the SNPs in promoter elements has been defined in several genes. However, the SNPs, which are part of the coding sequences of genes, have been difficult to define. Models to define the messenger RNA stability (Mfold analysis) have been developed. However, such a correlation in terms of end product as protein is still confusing. A number of attempts have been made to decipher the gene function of individual SNP variant, what is referred as “allelic expression variant” of haplotype as compared to wild type. In this context it is noteworthy that allelic variants have found to possess different activities.
