Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Review Article, J Virol Antivir Res Vol: 1 Issue: 2
Role of Coatomer Protein I in Virus Replication
| Jennifer A Thompson and Jay C Brown* | |
| Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia 22908, USA | |
| Corresponding author : Dr. Jay C. Brown Department of Microbiology, Immunology, and Cancer Biology, Box 800734, University of Virginia Health System, 1300 Jefferson Park Ave, Charlottesville, VA 22908, USA Tel: 434-924-1814; Fax: 434-982-1071 E-mail: jcb2g@virginia.edu |
|
| Received: July 20, 2012 Accepted: September 18, 2012 Published: October 30, 2012 | |
| Citation: Thompson JA, Brown JC (2012) Role of Coatomer Protein I in Virus Replication. J Virol Antivir Res 1:2. doi:10.4172/2324-8955.1000102 |
Abstract
Role of Coatomer Protein I in Virus Replication
Coatomer protein I (COPI) is well known as the protein coat surrounding vesicles involved in returning endoplasmic reticulum (ER)-resident proteins to the ER. COPI coats are also found in vesicles involved in other trafficking processes including endocytosis, autophagy and anterograde transport in the secretory pathway. In view of the diverse functions of COPI proteins, it is expected that they will affect virus replication, and many reports of such COPI involvement have now appeared. The experimental approaches most often employ specific siRNA to deplete COPI subunits or brefeldin A to block COPI activation.
