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Hindi Research Article, J Virol Antivir Res Vol: 2 Issue: 2
Ribavirin has an In vitro Antiviral Effect in Rabies Virus Infected Neuronal Cells but Fails to Provide Benefit in Experimental Rabies in Mice
| Camila Michele Appolinário1, Christophe Prehaud2,3, Susan Dora Allendorf1, João Marcelo Azevedo de Paula Antunes1, Marina Gea Peres1, Monique Lafon2,3* and Jane Megid1 |
| 1UNESP- School of Veterinary Medicine and Animal Science- Department of Veterinary Hygiene and Public Health, Botucatu, São Paulo, Brazil |
| 2Institut Pasteur- Unité de Neuroimmunologie Virale, Département de Virologie, Paris, France |
| 3CNRS, UMR3569, F-75015 Paris, France |
| Corresponding author : Monique Lafon Institut Pasteur- Unité de Neuroimmunologie Virale, Département de Virologie, Paris, France Tel: +33 1 45 68 87 52; Fax: + 33 1 40 61 33 12 E-mail: monique.lafon@pasteur.fr |
| Received: April 16, 2013 Accepted: June 24, 2013 Published: June 27, 2013 |
| Citation: Appolinário CM, Prehaud C, Allendorf SD, de Paula Antunes JMA, Peres MG, et al. (2013) Ribavirin has an In vitro Antiviral Effect in Rabies Virus Infected Neuronal Cells but Fails to Provide Benefit in Experimental Rabies in Mice. J Virol Antivir Res 2:2. doi:10.4172/2324-8955.1000111 |
Abstract
Ribavirin has an In vitro Antiviral Effect in Rabies Virus Infected Neuronal Cells but Fails to Provide Benefit in Experimental Rabies in Mice
The nucleoside analog ribavirin is one of the antiviral drugs recommended in the management of several viral infections in humans. Although ribavirin has been used in rabies treatment, its efficacy has not been formally proven. The objectives were to study the effect of ribavirin on rabies virus (RABV) infection in neuronal cultures, to analyze whether orally-given ribavirin activates an innate immune response in the brain and whether ribavirin confers protection against brain infection in a model of experimental rabies in mice.
