Novel Drug Delivery System to overcome Drug-Induced Hepatotoxicity

Hepatotoxicity is the injury or liver damage by exposure to drugs; it is an adverse drug reaction that may be common but serious. Most common hepatotoxic drug sulfonamide is used as our drug model. Diatom is widespread unicellular photosynthetic marine algae to produce exclusive extremely ordered silica cell wall (frustule). Diatom biosilica is suggested that targeting drug delivery and cost-effective transporter for water-insoluble medications applied in oral drug delivery system due to its high porosity, large surface area, modifiable surface, and biocompatibility. Most of the drug is continuously used, rapid metabolized and cause side effect. In the present study, we have envisaged the naturally occurring diatoms and its potential capacity in in vitro drug loading and release profile is a marine driven diatom with homogenous pore size distribution which can serve as a potential functional drug carrier. This work exhibits that the live marine diatoms can be a capable stage for targeted drug delivery is used owing to its stability, biocompatibility, cellular uptake, and drug release profiles.