Interferon lambda family along with HTLV-1 proviral load, tax, and HBZ implicated in the pathogenesis of myelopathy/ tropical spastic paraparesis

Introduction: HTLV-1 associated myelopathy/ tropical spastic paraparesis (HAM/TSP) is a chronic neuro-inflammatory disease related to human
T lymphotropic virus type 1 (HTLV-1) infection. Interferon type III (IFN-λ), which includes IL28, IL29, and IL28R, and affects the outcome of viral
infections, might be complicated in the progression of HAM/TSP.