HIV-Associated Multicentric Castleman Disease with Human Herpes Virus-8 Coinfection: A Case Report

Castleman Disease (CD) is a rare lymphoproliferative disorder classified into unicentric or multicentric variants. The Multicentric CD (MCD) involves diffuse lympadenopathy and the presence of type B symptoms (fevers, night sweats and weight loss), and relates to HIV/Human Herpes Virus (HHV)-8 infection. We report an MCD case of an HIV-infected 57 year old male patient. Histopathological examination showed Epstein-Barr Virus-Encoded small RNAs (EBERs) in addition to HHV-8 positivity with prednisolone and rituximab treatment, fever and pancytopenia were regressed. Multicentric CD should be considered in the differential diagnosis of patients presenting with lymphadenopathy and systemic symptoms. Patients with HIV-associated MCD should be followed routinely because of the relapsing and remitting nature of the disease.