Features of Cytokine Profile in Patients with Progressive TB-Induced Pulmonary Fibrosis Characterized by Various Intensities of Pulmonary Destructive Changes

Features of Cytokine Profile in Patients with Progressive TB-Induced Pulmonary Fibrosis Characterized by Various Intensities of Pulmonary Destructive Changes

Production of pro- and anti-inflammatory cytokines (IFN-γ, IL-2, TNF-α, IL-8, IL-4, IL-10) in patients with pulmonary TB infection with various spread and severity of the process were investigated in in vitro PPD- and PHA-stimulated peripheral blood mononuclear cells (PBMCs). It was demonstrated that each type of MDR-TB lung fibrosis is determined by specific traits of a multilevel cytokine network functioning according to activity of cytokine-producing cells.