Enriched developmental biology molecular pathways impacts on antipsychotics induced weight gain

Objective: Psychotropic induced weight gain (PIWG) may lead to increased risk for cardiovascular diseases, metabolic disorders and, ultimately, treatment discontinuation. The hypothesis tested in the present contribution was that PIWG might be genetically driven. The analysis of complete molecular pathways may grant a sufficient power to tackle the biologic variance of PIWG. The identification of a genetic makeup at risk for PIWG could characterize the subjects at risk for this possible severe side effect and helps move a step forward in the direction of personalized treatment in psychiatry.