Endothelial Function, Insulin Resistance, Serum Adiponectin Level in Rheumatoid Arthritis Females with Renal Dysfunction and Its Dynamics with L-Arginine Aspartate Supplementation

Purpose: To evaluate endothelial function, insulin resistance, serum adiponectin level in rheumatoid arthritis females with renal dysfunction and its dynamics with the L-Arginine aspartate supplementation

Materials and methods: 69 females with rheumatoid arthritis (RA) and renal dysfunction were enrolled. Patients were divided into group received L-Arginine aspartate and placebo group. Serum insulin, adiponectin were measured at the baseline and after 4 weeks. The level of insulin resistance, GFR was calculated. Determination of flow mediated vasodilation was performed at the baseline and after 4 weeks.

Results: EDVD was significantly lower among the RA females with renal dysfunction (p<0.05), serum adiponectin, IR level - significantly higher (p<0.05). It was estimated increased mean EDVD by 24.5% (p<0.001) with L-Arginine treatment. The level of insulin to the end of the study was lower on 20.3 % (p=0.002), insulin resistance – on 11.9 % (p=0.001) matched by НОМА1- IR and on 29.4 % (p=0.002) - by НОМА2-IR among patients received L-Arginine aspartate. The level GFR to the end of the study increased by 11.9 % (p=0.02).

Conclusions: Females with rheumatoid arthritis and renal dysfunction are characterized by high frequency endothelial dysfunction, adiponectin level changes, insulin resistance. Endothelial dysfunction correction in RA females with renal dysfunction with L-Arginine aspartate