A Diffuse Large B cell Lymphoma (DLBCL) With Central Nervous System Involvement in a HIV Positive Patient

 A Diffuse Large B cell Lymphoma (DLBCL) With Central Nervous System Involvement in a HIV Positive Patient

We present a case of a 18-year-old woman hospitalized in the Clinic of Hematology of Craiova (Romania) in September 2010 for a diffuse large B cell lymphoma-HIV associated, treated with intensive antiretroviral therapy (HAART) and eight cycles of rituximab-CHOP, with a good response (complete remission). After eighteen months, the patient relapsed in the central nervous system and develops a depressive syndrome. Central nervous system involvement is frequent in patients with secondary malignant lymphoma-HIV associated and may be expressed as neurological symptoms and psychiatric manifestations.