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Hindi Research Article, J Otol Rhinol Vol: 3 Issue: 5
Volume Expansion of Tissue Engineered Human Nasal Septal Cartilage
| Marsha S Reuther1,2*, Kristen K Briggs3,4, Monica K Neuman5,Koichi Masuda6, Robert L Sah3 and Deborah Watson1,2 | |
| 1Division of Otolaryngology-Head and Neck Surgery, University of California, San Diego, La Jolla, California, USA | |
| 2Head and Neck Surgery Section, VA San Diego Healthcare System, San Diego,California, USA | |
| 3Department of Bioengineering, University of California, San Diego, La Jolla,California, USA | |
| 4Research Service, VA San Diego Healthcare System, San Diego, California, USA | |
| 5Creighton University School of Medicine, Omaha, Nebraska, USA | |
| 6Department of Orthopedic Surgery, University of California, San Diego, La Jolla,California, USA | |
| Corresponding author : Marsha Reuther University of California, San Diego, Division of Otolaryngology-Head and Neck Surgery, 3350 La Jolla Village Drive, 112-C, San Diego, CA 92161, USA Tel: 858-642-3405; Fax: 858-552-7466 E-mail: mkadze@gmail.com |
|
| Received: May 18, 2014 Accepted: June 29, 2014 Published: July 10, 2014 | |
| Citation: Marsha S Reuther, Kristen K Briggs, Monica K Neuman, Koichi Masuda, Robert L Sah, Deborah Watson (2014) Volume Expansion of Tissue Engineered Human Nasal Septal Cartilage. J Otol Rhinol 3:4. doi:10.4172/2324-8785.1000172 |
Abstract
Volume Expansion of Tissue Engineered Human Nasal Septal Cartilage
Importance: Cartilaginous craniofacial defects range in size and autologous cartilaginous tissue is preferred for repair of these defects. Therefore, it is important to have the ability to produce large size cartilaginous constructs for repair of cartilaginous abnormalities.
Objectives: 1. To produce autologous human septal neocartilage constructs substantially larger in size than previously produced constructs 2. To demonstrate that volume expanded neocartilage constructs possess comparable histological and biochemical properties to standard size constructs 3. To show that volume expanded neocartilage constructs retain similar biomechanical properties to standard size constructs.
Design: Prospective, basic science.
Setting: Laboratory
Participants: The study used remnant human septal specimens removed during routine surgery at the University of California, San Diego Medical Center or San Diego Veterans Affairs Medical Center. Cartilage from a total of 8 donors was collected.
