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Hindi Research Article, J Liver Dis Transplant Vol: 1 Issue: 2
Sustained Glutathione Deficiency Interferes with the Liver Response to TNF-α and Liver Regeneration after Partial Hepatectomy in Mice
| Kimberly J. Riehle1,2, Jamil Haque2, Ryan S. McMahan2, Terrance J. Kavanagh3, Nelson Fausto2 and Jean S. Campbell2* | |
| 1Department of Surgery, University of Washington, Seattle, WA, USA | |
| 2Department of Pathology, University of Washington, Seattle, WA, USA | |
| 3Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA | |
| Corresponding author : Jean S. Campbell, PhD Department of Pathology, University of Washington, 1959 NE Pacific Street, Box 357705, Seattle, WA 98195-7705, USA Tel: 206-616-4796; Fax: 206-616-1943 E-mail: campjs@uw.edu |
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| Received: November 14, 2012 Accepted: January 10, 2013 Published: January 12, 2013 | |
| Citation: Riehle KJ, Haque J, McMahan RS, Kavanagh TJ, Fausto N, et al. (2012) Sustained Glutathione Deficiency Interferes with the Liver Response to TNF-α and Liver Regeneration after Partial Hepatectomy in Mice. J Liver: Dis Transplant 1:2. doi:10.4172/2325-9612.1000105 |
Abstract
Sustained Glutathione Deficiency Interferes with the Liver Response to TNF-α and Liver Regeneration after Partial Hepatectomy in Mice
Glutathione (GSH) is a tripeptide of glutamate, cysteine, and glycine. It is the most abundant non-protein thiol in the cell, and is present at 5-10 mM in hepatocytes. GSH scavenges reactive oxygen species (ROS) and acts as a cofactor in the metabolism of xenobiotics through reduction and conjugation reactions. Several methods have been used in vivo and in vitro to study the effects of short-term GSH depletion on the hepatocyte cell cycle.
