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Hindi Review Article, J Immunol Tech Infect Dis Vol: 3 Issue: 2
State of the Art on Plant-Made Single-Domain Antibodies
| Patricia Marconi and Maria A Alvarez* |
| CONICET/ School of Pharmacy and Biochemistry, Universidad Maimónides, Hidalgo 775 (1404), 6th floor, Ciudad de Buenos Aires, Argentina |
| Corresponding author : Maria A Alvarez CONICET/ School of Pharmacy and Biochemistry, Universidad Maimónides, Hidalgo 775 (1404), 6th floor, Ciudad de Buenos Aires, Argentina E-mail:alvarez.mariaalejandra@maimonides.edu |
| Received: February 26, 2014 Accepted: March 31, 2014 Published: April 04, 2014 |
| Citation: Marconi P, Alvarez MA (2014) State of the Art on Plant-Made Single-Domain Antibodies. J Immunol Tech Infect Dis 3:2. doi:10.4172/2329-9541.1000125 |
Abstract
State of the Art on Plant-Made Single-Domain Antibodies
In addition to conventional antibodies (with heavy and light chains), camelids also produce functional antibodies devoid of light chains (HCAbs) without the first constant domain (CH1). Their variable domains (VHH) have binding properties, high stability and solubility, and are considered the smallest available intact antigen–binding fragment derived from a functional immunoglobulin. For their practical utilities VHHs have been expressed in different platforms. This review aims to provide an update in the field of plant-made VHHs, their applications and limitations, and a discussion about the challenges for the near future in this field.
