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Hindi Editorial, Mol Med Ther Vol: 1 Issue: 1
Prolyl Hydroxylases in fight or flight
| Anne-Theres Henze1,2, Rodrigo Leite de Oliveira1,2 and Massimiliano Mazzone1,2* |
| 1Lab of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, Leuven, Belgium |
| 2Lab of Molecular Oncology and Angiogenesis, Vesalius Research Center, Department of Oncology, KU Leuven, Leuven, Belgium |
| Corresponding author : Dr. Massimiliano Mazzone Vesalius Research Center, VIB, KU Leuven, Campus Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium Tel: +32-16-37.32.13 E-mail: massimiliano.mazzone@vib-kuleuven.be |
| Received: July 28, 2012 Accepted: July 31, 2012 Published: August 11, 2012 |
| Citation: Henze AT, Leite de Oliveira R, Mazzone M (2012) Prolyl Hydroxylases in fight or flight. Mol Med Ther 1:1 doi:10.4172/2324-8769.1000e102 |
Abstract
Prolyl Hydroxylases in fight or flight
The fight or flight response was introduced by the American physiologist Walter Bradford Cannon at the beginning of the 20th century as a primary instinctive reaction of animals to a situation of danger. Applying this simplified point of view from behavioral research to studies of the cellular response to stress signals we are able to narrow down the complexity of the cellular system to either evading (“fleeing”) or resisting (“fighting”) growth-restricting conditions. We believe that the prolyl hydroxylase domain (PHDs) proteins function at important crossroads between these two extremes.