The relationship between MTHFR C677T gene polymorphism and essential hypertension in a sample of an Algerian population of the Oran city

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Asma Amrani-Midoun, Soto Romuald Kiando, Cyrielle Treard, Xavier Jeunemaitre and Nabila Bouatia-Naji

University of Oran 1 Ahmed Benbella, Algeria
INSERM, France
Paris-Descartes University, France
European Hospital Georges Pompidou, France

: Int J Cardiovas Res

Abstract

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Background: Many studies have investigated the role of 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in essential hypertension (EH), but with conflicting results. Aim: To determine the eventual association between 5,10-methylenetetrahydrofolate reductase (MTHFR ) C677T gene polymorphism and hypertension in a sample of Algerian population from the Oran city. Methods: A case-control study has been performed in 154 subjects including 82 hypertensives defined as subjects with elevated systolic blood pressure SBD≥140mmHg and or sustained diastolic blood pressure DBP≥90mmHg, and 72 normotensive subjects. Polymerase chain reaction (PCR) combined with restrictive fragment length polymorphism (RFLP) was used to detect the MTHFR C677T variant. Results: We observe no significant differences between allelic and genotypic frequencies between cases and controls for C677T polymorphism (OR=1.51, 95% CI= 0.89- 2.56, P=0.13). Analyses adjusted for age, sex and body mass index improved the association level, though the association was still not significant (30% vs. 22%, OR=1.75, 95% CI= 0.95-3.24, P=0.07). Conclusion: This work showed that genetic polymorphism related to the MTHFR gene (C677T) is not associated with the risk of hypertension in this sample of Algerian population. Larger case- control samples are required to clearly assess the role of this genetic variant in EH.

Biography

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Asma Amrani-Midoun is a lecturer. She belongs to Biotechnology Department, University of Oran 1 Ahmed Benbella, Oran, Algeria she is also Faculty of Sciences of Nature and Life, University of Oran 1 Ahmed Benbella, Oran, Algeria. She is corresponding author of article “The relationship between MTHFR C677T gene polymorphism and essential hypertension in a sample of an Algerian population of Oran city”.

E-mail: dr.asma.amrani@gmail.com