The effect of Iranian propolis on glucose metabolism, lipid profile, insulin resistance, renal function and inflammatory biomarkers in patients with type 2 diabetes mellitus: A randomized double blind clinical trial

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Maryam Jenabi, Mehrnoosh Zakerkish, Narjes Zaeemzadeh, Ali Asghar Hemmati and Niloofar Neisi

Ahvaz Jundishapur University of Medical Sciences, Iran

: J Pharm Sci Emerg Drugs

Abstract

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Introduction: Propolis is a natural product with many biological properties including hypoglycemic activity and modulating lipid profile. The present study was designed to evaluate the effect of Iranian propolis extract on glucose metabolism, Lipid profile, Insulin resistance, renal and liver function as well as inflammatory biomarkers in patients with type 2 diabetes mellitus (T2DM).

Methods: A double-blinde, Placebo-controlled clinical trial was conducted. In 90 days of study, recruited T2DM patients were randomly divided into an Iranian propolis group (1000 mg/day) (n=50) and a placebo group (n=44).

Results: At the end of the study, the serum levels of glycosylated hemoglobin (HbA1c), 2-hour post prandial (2hpp), insulin, homeostasis model assessment-insulin resistance (HOMA-IR), homeostasis model assessment of β-cell function (HOMA-β), High sensitive C-reactive protein (hs- CRP), tumor necrosis factor-α (TNF-α) significantly decreased and serum HDL-C was significantly increased in the propolis group compared with the placebo group. In the propolis group, serum liver transaminase (ALT and AST) and blood urea nitrogen (BUN) concentrations significantly decreased after 90 days.

Conclusion: Iranian propolis has beneficial effects on reducing post prandial blood glucose, serum insulin, insulin resistance and inflammatory cytokines also it can prevent the liver and renal dysfunction as well as can elevate HDL-C concentrations in T2DM patients.

Biography

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Maryam Jenabi is an experienced Clinical Specialist with a demonstrated history of working in the oil & energy industry pharmacies and hospitals. Skilled in Hospital Pharmacy, Clinical Research, Clinical Trial, Clinical Pharmacology, Drug Reconciliation, and Hospital Information Systems. Strong Drug consultant professional Pharmacist with a Doctor of Philosophy (PhD) focused in Clinical Pharmacology.

E-mail: jenabi_maryam@yahoo.com