Synthesis and hypolipidemic properties of novel N-(4-benzoylphenyl) pyrrole-2-carboxamide derivatives

<p>Tariq Al-Qirim</p>

Synthesis and hypolipidemic properties of novel N-(4-benzoylphenyl) pyrrole-2-carboxamide derivatives

Tariq Al-Qirim

Al-Zaytoonah University of Jordan, Jordan

: J Forensic Toxicol Pharmacol

Abstract

Hyperlipidemia is involved in development of atherosclerosis and coronary heart disease. We synthesized two novel pyrrole carboxamide derivatives N-(4-benzoylphenyl)-4-bromo-2,5-dihydro-1H-pyrrole-2 carboxamide (compound 1) and 4-amino-N-(4-benzoylphenyl)-1-methyl-1H-pyrrole-2 carboxamide (compound 2) and test them as antihypelipidemic agents. The synthesized compounds were characterized using I.R. and NMR. Biological evaluation of compound 1 and 2 showed that compound 1 significantly decreased TG, LDL-C, TC and mild increase in HDL-C in plasma. Contrarily, compound 2 appeared to be less potent compared to 1; it moderately decreased TG, LDL-C and TC with mild increase of HDL-C. The NH pyrrole mediates H-bond interaction of 1 with the backbone of the target(s) protein(s) and this corresponds to the high potency of 1. The lower activity of 2 confirms that the presence of H-bond is essential to induce high activity. The finding of this work suggests that this scaffold might be promising as antihypelipidemic agents for future work.

Email: pharmacy@zuj.edu.jo