Surface-engineered lanthanide cation-doped y-maghemite nanoparticles (nps) - innovative nps functionalization/nanoscale drug delivery for effective anti-leishmania bioactivity

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Lellouche J P

Bar-Ilan University, Israel

: J Nanomater Mol Nanotechnol

Abstract

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Iron oxide (FexOy) nanoparticles (NPs) are widely used in numerous biotechnology applications (magnetismdriven cell separation/cell tracking, magnetic field-guided drug/gene delivery, non-invasive tissue MRI, anti-cancer hyperthermia). But serious drawbacks like challenging detrimental NPs aggregation and controlled NPs surface functionalization versatility request quite innovative solutions. Our recent R&D work in this field led to the discovery of a novel method/concept for promoting (i) the effective anti-aggregation control of 5.0-6.5 nm-sized hydrophilic super-paramagnetic maghemite (-Fe2O3) NPs, and (ii) its successful use for NPs functionalization/versatile NPs surface engineering toward siRNA-mediated gene delivery/silencing cancer/anti-parasitic therapy-relevant applications. Such an innovative multi-parametric NPs surface engineering methodology exploits both globally optimized controlled Design Of Experiment (DoE) (i) highpower ultrasound (US)-assisted lanthanide metal Ce(III/IV) cation/complex doping, and (ii) polymer/small ligand-based NPs surface engineering towards innovative drug deliveryrelating maghemite NPs. Interestingly, this powerful critical 1st step Ce3/4+ cation/complex-doping process enabled an effective highly positive charge control of problematic NPs aggregation and full NPs water compatibility for a wide range of biological applications. Quite significantly, it also enables the effective development of versatile surface engineering coordinative linkages/chemistries using wellknown effective Ce3/4+Ln cation/complex-based coordination capabilities via any potential Lewis basis biomolecule/ organic species (hyaluronic/alginic acids, 25kDa branched polyethyleneimine (25bPEI), anti-Leishmania Pentamidine (Pent) drug, etc.…) simultaneous covalent binding. This versatile DoE-globally optimized NPs surface engineering enabled the discovery of specifically DoEoptimized surface-chemically modified hybrid Pentamidinecontaining functional -Fe2O3 NPs that disclosed highly powerful anti-parasitic (anti-Leishmania) bioactivity (both in vitro/in vivo effectiveness).1-3

Biography

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J-P Lellouche (PhD degree, 1981-University Claude Bernard/La Doua, Lyon, France) joined the Department of Chemistry/Institute of Nanotechnology & Advanced Materials (BINA) at Bar-Ilan University since October 2000 as Full Professor (Organic Chemistry/Nano(bio)technology - July 2008) & Chemistry Dpt Head (Oct 2017). His main R&D activities includes R&D cutting-edge Materials Science level interfacing with nano(bio)technology. He has authored 149 papers. His main research interests focus on conductive polymers, sol-gel & polymeric surfaces/matrices/NPs, MRI & drug delivery/gene silencing, antibacterial/anti-parasitic nanomaterials and coatings, UV-photoreactive particles for surface nano(micro)structuration of polymeric coatings, catalytic particles (fuel cell technology), & transition metal dichalcogenide nanostructures.

E-mail: Jean-Paul.M.Lellouche@biu.ac.il