Spectrophotometric method for determination of phenylephrine-HCl in pharmaceutical dosage forms

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Shlair H Hasan

University of Salahaddin, Iraq

: J Pharm Drug Deliv

Abstract

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This study represents a new simple spectrophotometric method for determination of phenylephrine hydrochloride (PHE-HCl) based on formation of ion-pair associates between drug and inorganic complex, bismuth (III) tetraiodide in pure form and tablet formulations. The reaction occurs in acidic medium to form orange- red ion-pair associates which are instantaneously precipitated. The formed precipitate then filtered off and the residual unreacted metal complex in the filtrate was determined spectrophotometrically at 455 nm. Beer’s law was valid over the concentration range of 5.0-60 μg/ml PHE. The proposed method was successfully applied to determine PHE in its tablet formulations without any evidence for interference from pharmaceutical additives. The results were in good agreement with those obtained by the reference method.

Biography

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Email: blndmuh@yahoo.co.uk