Preparation and application of a novel intact solid lipid nano-vesicles

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Zhijun Yang and Aiping Lu

Hong Kong Baptist University, Hong Kong

: J Pharm Drug Deliv Res

Abstract

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We have successfully achieved the preparation of intact solid lipid nano-vesicles that carry active pharmaceutical ingredients (API) and upon rehydration form liposomes with controlled drug release capability. To demonstrate this, solid lipid nanovesicles were prepared by lyophilizing the mixture of liposomes combined with or without ligands such as DSS or CA9, entrapped water-soluble API such as albuterol or siRNA or insulin, mixed with cryo-protectant lactose and a plasticizer glycerol and water. Liposome structure, entrapped API and controlled release capability were retained after lyophilization and rehydration, and the in vivo delivery effectives were confirmed. Since solid lipid nano-vesicles are more adaptable than liposomes or other nanoparticles to a wide variety of APIs and dosage forms, our novel invention allows a much wider usage of liposome technology in numerous pharmaceutical, chemical and biological situations.

Biography

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