Novel Small Bioactive Compounds for the Control of Melanoma Cell Proliferation and Migration

---

Qurat-ul-Ain Karin Scharffetter-Kochanek and M. Iqbal Choudhary

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biolog

: J Appl Bioinforma Comput Biol

Abstract

---

Melanoma is a deadly form of skin cancer due to its high propensity to metastasize through the critical processes of cell migration and invasion. Out of many synthetic molecules, eight compounds (compounds 1, 2, 3, 4, 5, 6, 7 and 8) have been selected as the most effective anti-melanoma molecules for their capacity to reduce in vitro cell proliferation and migration. These compounds are now being further investigated with the aim of understanding their mechanism of action. The most effective molecules, with a potent and selective action against melanoma cells, will be used in animal models and as templates for developing even more potent and specific antimelanoma compounds both in vitro and in vivo.

Biography

---

Qurat-ul-Ain, is a Ph.D student at Dr.Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi. She is collaborative Research Student at Department of Dermatology and Allergy University of Ulm Germany, Ms. Qurat-ul-Ain has characterized a variety of newly designed chemical compounds in term of their antioxidant and pro-oxidant properties. She studies these in melanoma cell and melanocytes. Some of the studied compounds reveal an inhibitory effect on melanoma cells, but not on their benign counterpart, the melanocyte. The mechanisms of action of these compounds are being investigated. Qurat-ul-Ain has authored 19 articles published in international journals