Noncompliance with surgical antimicrobial prophylaxis guidelines: A Jordanian experience in cesarean deliveries

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Mariam Hantash Abdel Jalil, Khawla Abu Hammour, Mervat Alsous Rand Hadadden, Wedad Awad, Faris Bakri and Kamil Fram

University of Jordan, Jordan
Applied Science Private University, Jordan
Jordan University Hospital, Jordan

: Androl Gynecol: Curr Res

Abstract

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Background: Surgical site infections are common, especially in developing countries. Nevertheless, up to 60% of surgical site infections can be prevented with appropriate perioperative care, which includes among other measures using suitable surgical antimicrobial prophylaxis (SAP). Methods: After a short interview with patients and retrospective review of medical charts, compliance with 6 SAP parameters was assessed for appropriateness; those parameters are indication, choice, dose, time of administration, intraoperative redosing interval, and duration of prophylaxis in 1,173 operations. Results: Overall compliance was poor; nevertheless, certain components showed high compliance rates, such as indication and choice of antibiotics. The most frequent error noted was extended administration of prophylactic antibiotics, which was observed in 88.2% of the study population. Emergency operations were associated with a lower risk of noncompliance in administering the correct dose at the correct time (odds ratio, 0.63; 95% confidence interval, 0.47-0.83 and odds ratio, 0.21; 95% confidence interval, 0.14-0.3, respectively). On the other hand, women who underwent an emergency operation were associated with a 6-fold higher risk of receiving prophylactic therapy following surgery. Conclusions: The present study demonstrated the existence of a surprisingly low level of overall compliance with the hospitaladapted SAP guidelines. Factors implicated in noncompliance were investigated, and the present results create a starting point to improve the current practice.

Biography

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Mariam Hantash Abdel Jalil is a Assistant Professor of Clinical Pharmacy in the Faculty of Pharmacy/University of Jordan. Her main research interests include: Pharmacy practice, adherence to medications/ compliance with guidelines, medication errors, pharmacokinetics modeling and simulation, pharmacogenetics, and health informatics.

E-mail: e: m.abdeljalil01@yahoo.com