Nitric oxide, superoxide anion, malondialdehyde and nutritional profile in colorectal cancer in the West of Algeria

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Badid Naima, Merzouk Hafida and Medjdoub Amel

University Abou-Bekr Belkaïd, Algeria

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Abstract

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Colorectal cancer (CRC) ranks second in terms of incidence and mortality in Algeria, because of the number of cases increasing steadily each year. The major risk factors in relation to the CRC are still essentially lifestyle (Sedentariness, low physical activity, diet troubles and tabacco). The case-control study concerns 20 cases of CRC and 30 controls of male encompasses the risk factors in the development of the CRC in the population of the Wilaya of Tlemcen (Western region of the Algeria). Glucose, lipids, LDLcholesteryl ester, markers of oxidant status (malondialdehyde, nitric oxide and superoxide anion) was investigated in CRC patients and in control male. Also a food survey was guided in the same population. Our findings showed that the CRC patients reach at health services with a Stage III at 60% and a Grade II at 70%. Body mass index, lifestyle and hereditary predisposition are identified as CRC risk factors. In this population, CRC is associated with tobacco active and passive consumption, sedentariness, low physical activity, significantly lower oilseed intake. A hypo-albuminemia was revealed, LDL-Cholesterol, uric acid, nitric oxide (NO.), superoxide anion (O2.) and malondialdehyde (MDA) concentrations were significantly increased in patients compared to controls. In conclusion, CRC is associated with lipid alterations and increased oxidative stress linked to NO., O2. and MDA and low levels in physical activity.

Biography

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Email: badidnaima@gmail.com