Measurement of skin antioxidant activity by the PAOT-Skin® Technology. Relationship with blood and urinary biomarkers of skin oxidative stress

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Meziane Smail

European Institute of Antioxidants, France

: J Clin Exp Dermatol Res

Abstract

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According to Jones, oxidative stress (OS) has been defined as an imbalance between reactive oxygen species or ROS (including free radical and non-free radical species) and antioxidants in favor of the formers, leading to a disruption of the redox signaling and/or molecular damage to lipids, proteins and DNA. A promising but always under explored way to evidence OS is to use skin as a matrix. Having the largest surface area in the body, skin is a major target for oxidative stress, as it is continually exposed to external aggressions. The present talk is devoted to the potential use of the PAOT-Skin® technology based on electrochemical application for evidencing OS in a non-invasive way in the skin matrix. Data related to robustness and validation of the method will be examined. In a study performed on 30 healthily subjects, we were able to evidence a negative and significant correlation between the PAOT-skin score ® and blood lipid peroxides (r = -0.43, p = 0.020), copper (r = -0.42, p = 0.022) and the Cu / Zn ratio (r = -0.49, p = 0.006). Statistical analysis revealed that the PAOT-skin score ®was positively correlated with the gamma-tocopherol/alpha-tocopherol ratio (r = 0.43; p = 0.020). Further studies are under investigation to test PAOT-skin score® in populations known to be submitted to high OS such as smokers or patients having type II diabetes, cardiovascular diseases or cancer.

Biography

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Dr. Smail MEZIANE, obtained PhD degree in Biotechnology and Food Process (University of Lorraine-ENSAIA-Nancy France) and a Master in Agricultural and Food Engineering (University of Haute Alsace-France). He taught at the Nancy Faculty of Medicine, University of Lorraine and served as head of the Health Engineering license option "Human Nutrition". He invited professor in Congo - Brazzaville (Unesco-Marien Ngouabi University) and Kazakhstan (University of Shimkent Kazakhstan). He has made several research trips to Russia and Japan, Argentina in collaboration. He is a lecturer at European Center for Research, Development and Education in Nutrition and Nutritherapy (CERDEN). He is a Lecturer and member of the Algerian Society of Nutrition and Orthomolecular Medicine (SANMO) and member of the International Society of Molecular Medicine (ISOM).