Low prevalences of HIV infection and HSV genital shedding in the general adult female population in Senegal

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Silman Diawara, Laurent Belec, Ahmadou Dem, El Hadji Seydou Mbaye, Halimatou Diop Ndiaye, Mathieu Matta, Sokhna Bousso Gueye,Souleymane Mboup and Coumba Toure Kane

University Cheikh Anta Diop de Dakar, Senegal
Hopital Militaire de Principal, Senegal
Public Assistance – Paris Hopitals, France
Paris Descartes University, France
Institut Juliot Curie, Senegal

: J Virol Antivir Res

Abstract

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Introduction: Herpes simplex virus (HSV) is the main co-factor for heterosexual transmission of the human immunodeficiency virus (HIV) in sub-Saharan Africa and could be involved in the dynamics of the HIV epidemic in Senegal.

Methodology: Genital shedding of HSV was evaluated in adult females who had visited the provincial healthcare centres in Diass, Louga and Kebemer in Senegal. Study subjects were interviewed by a healthcare worker for sociodemographic characteristics and sexual behavior and HIV serology was offered. In addition, cervical secretion lavage samples were evaluated for HSV DNA by real-time polymerase chain reaction (PCR), the melting curve analysis of which permitted distinction between HSV type 1 (HSV-1) and HSV type 2 (HSV-2).

Results: Among 302 women (mean age, 40 years) enrolled, none were infected by HIV. The mean age at first sexual intercourse was 20 years and the mean number of sexual partners in the previous year was 1.3 (range, 1–7). Only 6 of 302 (1.9%) women had cervicovaginal secretions positive for HSV DNA. No association between HSV DNA shedding and any sociodemographic or biological variables was found. Surprisingly, genital shedding of HSV-1 was found in two (0.7%) women, representing 33% of herpes-shedding women and HSV-2 in four (1.5%) women.

Conclusions: The observations indicate a low prevalence of HSV DNA genital shedding in adult Senegalese women.

Biography

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E-mail: seydou27@hotmail.com