Evaluation of antiproliferative and antioxidant activity of Swertia chirata

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Homa Jilani Khan, Mohammad Kaleem Ahmad, Abbas Ali Mahdi, Namrata Rastogi, Jamal Akhtar Ansari, Nishat Fatima and Abdul Rahman Khan

Integral University, Lucknow, India
King George’s Medical University, India

: J Plant Physiol Pathol

Abstract

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The objective of this study was to investigate anti-proliferative effects of the Swertia chirata (SCME) methanolic extract against human breast cancer cells MDA-MB-231 and MCF-7 in a dose and time-dependent manner. Our experimental findings demonstrated significant positive results. Microscopic assessment of cellular and nuclear morphology of SMCE treated human breast cancer cells indicated apoptosis as a mode of cell death. Anti-oxidant profiling of SCME also indicated presence of high concentration of polyphenols and anti-oxidant enzymes like SOD and Catalase with potent free radical scavenging activity. Further studies are required for isolation and characterization of specific bioactive compounds in SCME and determination of their mechanism of action responsible for their anti-proliferative activity.

Biography

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Email: khan.homajilani@ymail.com