Effect of Acetazolamide on cytokines in rats exposed to high altitude hypoxia environment

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Rong Wang, Chang Wang, Hua Xie, Wenbin Li, Hui Lu and Zhengping Jia

Lanzhou General Hospital, China

: J Pharm Drug Deliv Res

Abstract

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Introduction: It was known the relationship between environment and immunity as a result of the interaction between neuroendocrine and immune systems. Environmental conditions (hypoxia, temperature, physical exercise) represent some of the stimuli that may influence the functional behavior of immunocompetent cells [1]. Many parameters include the evaluation of cytokine expression and lymphocyte subsets in relationship to hormone production and strenuous exertion have been considered [2]. Both acute and chronic hypoxia is known to influence cytokine levels [3]. More and more articles [4,5] reported that hypoxia cause systemic inflammatory response, which was the major factor causing high altitude multiple organ dysfunction syndromes. In this paper, we designed to rapidly exposure to the high-atitude areas, studied the influence of acute exposure to high altitude on the body and screened for the major cytokines that might be involved in the development of high altitude disease

Biography

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Conclusion: In summary, the results indicate that the exposure to high altitude and the consequent hypoxia are able to alter a number of cellular and functional immunologic parameters. Further studies in other subjects are needed to evaluate the physiologic significance of these changes, particularly in terms of chemokine and cytokine expression. wangrong-69@163.com