Cubosomes: A Promising Nano carrier of Immense Therapeutic Value

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Ram Sharnagat Thakur

Jadavpur University, India

: J Pharm Drug Deliv Res

Abstract

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In the safety and efficacy conscious regulatory regime, nanomedicines offer promising prophylactic and therapeutic advantages. Nano carriers provide technological approach as an ideal vehicle that targets drug delivery to cells/tissues, increase bioavailability, improve safety and sustain drug effect. In future many ailments may be evaded because Nano devices can protect against infection or overcome biochemical imbalances in the body that result in complicated diseases. Human health issues are because of disturbances in the biological system at molecular level. The projected figure of global market for nanotechnology based drug delivery systems is $118,527.2 MN by 2023. This professes high research potential in this field to address product related limitations in terms of pay-load, stability, targeted delivery, in vivo distribution profile, and effectiveness and safety profile of the formulation. The landscape of pharmaceutical dosage forms is bound to change in times to come. The conventional macroscopic dosage forms are bound to be replaced by sub microscopic systems and smart formulations. As a futurist I believe, future of pharmaceutical industry lies in research investments on development of nanomedicines formulations. The area of nanotechnology research presented here is Cubosomes. Nanotechnology is applied in design and formulation of dosage delivery systems. Cubosomes as liquid crystal cubic phase of continuous nature exhibit very high potential and unique properties as nan carrier for hydrophilic, lipophilic or amphiphilic drugs. This beauty or feature of Cubosomes solves drug solubility related problems and in turn bioavailability concerns, blood-brain barrier issues etc. Bioavailability is the basis of pharmacological effect and therapeutic outcomes obtained from a drug. Cubosomes as Nano carrier has advantage of transporting the drug for interaction with receptors in the body at subcellular or molecular level with specificity to diseased tissue/targeted organ. This in turn avoids exposure of healthy tissue and increases safety. Research priorities of both academia and industry are shifting from imitation to innovation. Hence research utilizing a latest development in different branches of science and technology has become order of the 21st century. Cubosomes are self-assembled liquid crystalline phase having bicontinuous structure made of lipid and stabilized by outer corona of polymer. Because of unique internal structure it has potential to accommodate drugs of varying molecular size.

Biography

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Dr. Ram Sharnagat Thakur (R.S.Thakur), Director Professor, Krupanidhi College of Pharmacy.D. Pharm., Pharmacy School, Agamkuan, Patna-800 007, (1970), B. Pharm (Hons), Jadavpur University, Kolkata-700032, (1981), M. Pharm. Jadavpur University, Kolkata-700 032, (1983), Ph. D.(Pharm.), Jadavpur University, Kolkata-700 032, (2000).Pharmacist, one year, Government of Bihar, Department of Revenue, N. T. C. hospital, Bettiah, Champaran, Bihar. Pharmacist, 9.5 years, AMD, Dept. of Atomic Energy, Govt. of India. Manager (QC and R&D), 9 months, R. B. Laboratories, Calcutta-75.Senior Research Fellow, 3.5 years, Jadavpur University, Calcutta-32.Asstt.