Cichorium intybus attenuates streptozotocin induced diabetic cardiomyopathy via inhibition of oxidative stress and inflammatory response in rats

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Manju Sharma

Hamdard University, India

: J Pharm Drug Deliv

Abstract

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The aim of the present study was to investigate the effects of Cichorium intybus (CI) on lipid peroxidation, activities of both enzymatic and non-enzymatic antioxidants, inflammatory mediators, myocardial enzymes and histopathology of cardiac tissues in experimental diabetic cardiomyopathy (DCM). Diabetic cardiomyopathy was induced by single intraperitoneal injection of STZ (40mg/kg) combined with high energy intake in rats. CI (250mg and 500mg/kg) was administered orally once a day for 3 weeks. Phytochemical investigations of seed extract revealed the presence of some active ingredients such as alkaloids, tannins, saponin, phenols, glycosides, steroids, terpenoids and flavonoids. An elevation of the levels of aspartate aminotransferase (AST), blood glutathione (GSH), lactate dehydrogenase (LDH), superoxide dismutase (SOD), thiobarbituric acid reactive substances (TBARS), TNF-α and IL-6 and a reduction in the levels of catalase (CAT) was observed following the STZ treatment. Oxidative stress was accompanied by myocardial degeneration as evidenced by histopathological examination of cardiac tissues. Administration of CI reduced the lipid peroxides level in heart. Serum levels of AST, GSH, LDH and SOD were brought down to physiological levels by CI in STZ induced DCM rats. CI also markedly down-regulated serum TNF-α and IL-6 levels. Catalase that was reduced in serum was brought back to near normal level. The extensive necrotic changes of cardiac tissue by STZ were minimized to normal morphology upon CI administration. The study demonstrates the cardioprotective effect of CI via inhibition of oxidative stress and pro-inflammatory cytokines.

Biography

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Email: manju_sharma72@yahoo.com