Carboxymethyl sago pulp: A smart polymer for ph sensitive release

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Saravanan Muniyandy

Monash University, Malaysia

: J Pharm Drug Deliv Res

Abstract

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Carboxymethyl sago pulp (CMSP) with a degree of substitution of 0.4% was synthesized from Malaysian sago biomass. Because of the carboxyl functional group, CMSP shows a pH depended solubility. Drug loaded CMSP beads were formed by ionotropic gelation and further cross-linked by irradiation. 5-aminosalicylic acid (5-ASA), a model drug was encapsulated in CMSP beads to target the release in the colon. Fourier-transform infrared spectroscopy and X-ray diffraction studies indicated intact and amorphous nature of entrapped drug. The beads showed pH dependent sustained release over 9 h, and more than 90% of the drug was released only at pH 7.4. Irradiated beads were resisted the drug release in acidic environment at a higher extent than the non-irradiated beads. The swelling behaviour of the beads depended on polymer content and extent of cross-linking. The release exponent n value suggested a non-Fickian transport of 5-ASA.

Biography

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Saravanan has completed his Masters in Pharmaceutics at the age of 24 years and PhD at the age of 32 years from Chennai, India. He has also completed GCHE at Monash University. Saravanan has nearly 20 years of experience in teaching pharmacy graduates and supervising research students. Presently, He is the Deputy Head, School of Pharmacy, Monash University, Malaysia. He has published more than 30 research papers in reputed journals and has been serving as peer reviewer for several high-quality journals. He is also an editorial board member of reputed journals.

E-mail: saravanan.muniyandy@monash.edu