Antiradical, antiacetylcholinesterase, antibutyrylcholinesterase and anticarbonic anhydrase properties of olivetol (5-n-amylresorcinol)

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Parham Taslimi, Ä°lhami Gulcin

Ataturk University, Turkey

: J Pharm Sci Emerg Drugs

Abstract

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Olivetol is a pioneer in diverse syntheses of tetrahydrocannabinol (THC). a type of insects, which used as a pheromone, antiseptic or repellent, produces 5-Pentylresorcinol. In this study, we evaluated the antioxidant properties of olivetol in vitro using various procedures. These; Fe3+-Fe2+reducing, Cu2+-Cu+ reducing, Fe3+-TPTZ reducing, DPPH• scavenging, ABTS•+ scavenging, DMPD•+ scavenging, super oxide scavenging, Fe2+ chelating. The IC50 values of the olivetol in the DPPH•, ABTS•+, DMPD•+, O•2- and metal chelating assays were 17.77, 1.94, 19.25, 53.30, 2.83 μg•mL-1, respectively. In this paper, Olivetol compound showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II, acetylcholine esterase (AChE), and butyrylcholinesterase (BChE). For Olivetol which had Ki value of 88.05±11.15 nM against hCA I 178.27±35.94 nM against hCA II, respectively. On the other hand, the Ki value was found of 3.40±0.34 nM against AChE and 2.73±0.18 nM against BChE, respectively.

Biography

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E-mail: parham_taslimi_un@yahoo.com