Antimicrobial studies of arylidene acetophenone derivaties from Benzimidazoles

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Abiodun Shittu

Chippy Regi, Meena Chandran, K Krishnakumar, A R Bhat and B Dineshkumar

: J Pharm Drug Deliv Res

Abstract

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St. James College of Pharmaceutical Sciences, India

Biography

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The present study was designed to synthesis different arylidene acetophenone derivatives (chalcones) of benzimidazole using o-phenylene diamine and lactic acid as the starting materials. Synthesized compounds were subjected to both antibacterial studies with Staphylococcus aureus NCIM 2079, Bacillus subtilis NCIM 2439, Escherichia coli NCIM 2118 and Pseudomonas aeruginosa NCIM 5029 and antifungal studies with Candida albicans and Aspergillus niger. The results indicated that the synthesized compounds S1, S2 and S3 showed considerable antibacterial and antifungal activities. This study suggested that the compound S3 can be identified as antimicrobial molecule.

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