Unusual Sanctuary Site (Central Nervous System) Metastases in Gastrointestinal Stromal Tumor Patients

Amanda Parkes^1,2*, Filip Janku³, Shubham Pant³ and Neeta Somaiah⁴

¹The University of Texas MD Anderson Cancer Center, Division of Cancer Medicine, U.S.A

²University of Wisconsin Carbone Cancer Center, U.S.A

³Department of Investigational Cancer Therapeutics, U.S.A

⁴Department of Sarcoma Medical Oncology, U.S.A

*Corresponding Author :Amanda Parkes
Mailing Address: 600 Highland Avenue, K4/530 Clinical Science Center, Madison, WI, U.S.A
Tel: 608-265-4178
E-mail: amparkes@medicine.wisc.edu

Received: March 06, 2020 Accepted: March 12, 2020 Published: April 02, 2020

Citation: Citation: Parkes A, Janku F, Pant S, Somaiah N (2020) Unusual Sanctuary Site (Central Nervous System) Metastases in Gastrointestinal Stromal Tumor Patients. Clin Oncol Case Rep 3:4.

Abstract

Gastrointestinal Stromal Tumor (GIST) metastases occur in 18%- 47% of patients and most commonly involve the liver and peritoneum. Central Nervous System (CNS) and other sanctuary site metastases are rare, with only limited single patient case reports available in the literature. Given the availability of multiple effective treatments and longer life expectancy in patients with metastatic GIST, there is an increased likelihood of metastases to sanctuary sites including the CNS. We sought to characterize three GIST patients who developed these rare sanctuary site metastases between 2017-2018 during their course of therapy and compare their clinical features and molecular profiles, to add to current knowledge and highlight the need for clinicians to consider sanctuary site metastases, particularly in patients presenting with new symptoms.