Transdermal Iontophoresis of Non-Polar Drugs: A Mini Review

Praneeth Rao Kakulamarri¹, Kanaka Latha Alikatte² and Uday Venkat Mateti^3*

¹Ascent Pharmaceuticals, Central Islip, New York, USA 11722

²Department of Pharmacology, St. Peter’s Institute of Pharmaceutical Sciences, Warangal, AP 506001, India

³NGSM Institute of Pharmaceutical Sciences, Nitte University, Mangalore, Karnataka, India

Corresponding author : Uday Venkat Mateti, PhD  NGSM Institute of Pharmaceutical Sciences, Nitte University, Mangalore, Karnataka, India Tel: +918152977460 E-mail: udayvenkatmateti@gmail.com

Received: August 09, 2016 Accepted: August 19, 2016 Published: August 22, 2016

Citation:Kakulamarri PR, Alikatte KL, Mateti UV (2016) Transdermal Iontophoresis of Non-Polar Drugs: A Mini Review. J Pharm Drug Deliv Res 5:3. doi:10.4172/2325-9604.1000151

Transdermal Iontophoresis of Non-Polar Drugs: A Mini Review

Abstract

Transdermal iontophoresis is one of the most studied active technique involves passage of small electrical current to drive the charged drug molecules through the skin. However, iontophoresis is not suitable for nonpolar drugs as they lack any charge and possess poor water solubility. Therefore, the main objective of this review was to discuss the potential approaches to render the lipophilic drugs amenable to iontophoretic delivery across the skin.