The Interaction between Metformin and Bile Acids in Metabolic Disease

Jianting Li¹, Yang Liu² and Shuguang Pang^1*

¹Endocrinology Department of Jinan Central Hospital affiliated to Shandong University, No. 105, Jie fang Road, Jinan City, Shandong Province, 250013, P.R. China

²School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia Qld, 4072, Australia

*Corresponding Author : Shuguang Pang, PHD & MD
Endocrinology Department of Jinan Central Hospital affiliated to Shandong University, No. 105, Jie fang Road, Jinan City, Shandong Province, 250013, P.R. China
Tel: 86-15318816292
E-mail: shuguangpang@163.com

Received: July 10, 2017 Accepted: July 26, 2017 Published: July 31, 2017

Citation: Li J, Liu Y, Pang S (2017) The Interaction between Metformin and Bile Acids in Metabolic Disease. Endocrinol Diabetes Res 3:2. doi: 10.4172/2470-7570.1000123

Objective: To review the function of bile acids and the mechanism of metformin in lipid and glucose metabolism, and the interaction between metformin and bile acids.

Methods: PubMed and Google Scholar were searched using terms such as bile acid, lipid, glucose, metformin and type 2 diabetes. Additional relevant references were identified by reviewing the reference lists of articles.

Results: Bile acids are important molecules of regulating glucose and lipid metabolism through FXR and TGR5, while metformin through AMPK signaling pathway. Regulator role of metformin in glucose and lipid metabolism might be associated with bile acid metabolism.

Conclusions: Metformin as a welcomed antidiabetic drug can modulate glucose level via bile acids secretion. Keywords Metformin; Cholesterol; Antidiabetic drug; Bile acids; Type 2 diabetes