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Hindi Review Article, J Genet Disor Genet Rep Vol: 5 Issue: 1
Telomeres in Cancer: Length, Positioning and Epigenetics
| Patel TN*, Sulekha R Nair, Lekshmi Mohan, Fahmina Y, Ashwini Devi S and VA Saimadhukiran Dabbiru |
| Division of Medical Biotechnology, SBST, VIT, Vellore 632014, Tamilnadu, India |
| Corresponding author : TN Patel, Associate Professor Division of Medical Biotechnology, SBST, VIT, Vellore-632014, Tamilnadu, India Tel: 9597873669 E-mail: tnpatel@vit.ac.in |
| Received: November 03, 2015 Accepted: January 21, 2016 Published: January 27, 2016 |
| Citation: Patel TN, Nair SR, Mohan L, Fahmina Y, AshwiniDevi S, et al. (2016) Telomeres in Cancer: Length, Positioning and Epigenetics. J Genet Disor Genet Rep 5:1. doi:10.4172/2327-5790.1000131 |
Abstract
Telomeres, the tandem nucleotide sequences at the termini of the DNA, enables the masking of DNA from repair mechanisms, thus protecting them from being considered as double stranded breaks. When the maintenance of telomeres goes awry, several diseases including cancer are resulted. Here in this review, we give an account of how telomere shortening, lengthening, positioning in the nucleus and its associated epigenetic modifications set cancer cells apart from normal cells.
