Targeted drug delivery of injectable in situ gel of Methotrexate sodium for the treatment of Rheumatoid Arthritis

The present study aims to develop MTX-S (Methotrexate sodium) in situ gels as an effective way for the treatment of rheumatic arthritis (RA). The in situ gels composed of Pluronic F-127 as a polymer and Hydroxy Propyl Methyl Cellulose K4M (HPMC K4M) and Polycarbophil (PCL) as copolymers were manufactured by cold method. The in situ gels were characterized for gelation time, gelation temperature, syringeability, viscosity, sterility, in vitro release and drug content.