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Hindi Case Report, Int J Ment Health Psychiatry Vol: 1 Issue: 3
Tacrolimus induced Mania with Psychosis - A Case Report
| Shailesh Jain*, Yu Hsuan Liao and Duy Li | |
| Department of Psychiatry, Texas Tech Health Science Center, School of Medicine - Permian Basin, Odessa, Texas, USA | |
| Corresponding author : Shailesh Jain MD MPH, ABDA, Associate Professor, 301 North N Street, Midland, Texas, USA, 79701, 432-620-1046 Fax: 432-620-5837 E-mail: bobby.jain@ttuhsc.edu |
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| Received: September 22, 2015 Accepted: November 12, 2015 Published: November 16, 2015 | |
| Citation: Jain S, Liao YH, Li D (2015) Tacrolimus induced Mania with Psychosis - A Case Report. Int J Ment Health Psychiatry 1:3. doi:10.4172/2471-4372.1000110 |
Abstract
We are reporting a case of tacrolimus (Prograf) induced mania with psychotic features in a 68-year-old woman (Ms. A) with recent treatment for acute lymphoblastic leukemia (ALL). Neurotoxicity and delirium have been reported to occur with the macrolide immune suppressive tacrolimus in hepatic and renal allograph transplantations. In addition, nephrotoxicity and anxiety in renal transplants have been correlated with high trough tacrolimus blood concentrations (normal: 5-15 ng/ml, multi-enzymatic immunoassay). Our case is unique in that mania with psychotic features was noted even with subtherapeutic blood levels of tacrolimus (1.6 ng/ml), which did not respond to initial treatment with olanzapine.
