Short Communication, J Genetic Gene Ther Vol: 7 Issue: 1

Mechanism of Virology and its Function

Stella Daniela^*

Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy

*Corresponding Author: Stella Daniela
Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
E-mail: daniela.ss@gmail.com

Received: 03 March, 2023, Manuscript No. JGGT-23-93331; Editor assigned: 06 March, 2023, PreQC No. JGGT-23-93331 (PQ); Reviewed: 20 March, 2023, QC No. JGGT-23-93331; Revised: 27 March, 2023, Manuscript No. JGGT-23-93331 (R); Published: 06 April, 2023 DOI: 10.4172/Jggt.1000135.

Citation: Daniela S (2023) Mechanism of Virology and its Function. J Genetic Gene Ther 7:1.

Description

Virology is the branch of microbiology that deals with the study of viruses, including their structure, replication, and effects on their host cells. Viruses are infectious agents that are not classified as living organisms, as they are difficult to simulate or carry out metabolic processes without a host cell. Similarly, they control the machinery of their host cells to replicate and spread throughout the organism [1-3]. The study of virology is important in several fields, including public health, veterinary medicine, and agriculture. Viruses are responsible for a wide range of diseases, from the common cold to more serious illnesses such as HIV/AIDS, Ebola, and COVID-19. Understanding the basic biology of viruses is essential for developing effective vaccines and antiviral treatments to overcome these diseases [4].

One of the primary areas of study in virology is viral replication. Viruses are made up of a small amount of genetic material; either DNA or RNA, surrounded by a protein coat is called as a capsid. Some viruses have a lipid and protein-based external components. When a virus infects a host cell, it attaches to a specific receptor on the cell surface and injects its genetic material into the cell. The viral genome then inhibits the host cell's machinery to generate new viral particles [5,6]. The replication cycle of viruses can vary depending on the type of virus. Some viruses, such as HIV, integrate their genetic material into the host cell's genome, where it can remain dormant for years before reactivating and producing new viral particles. Other viruses, such as influenza, produce new viral particles inside the host cell and then bud off from the cell membrane to infect other cells [7].

Viral pathogenesis, or the study of how viruses cause disease, is another important area of virology. Once a virus infects a host cell, it can either remain dormant or produce new viral particles that can spread to other cells and tissues. The immune system of the host organism responds to the viral infection, triggering inflammation and other immune responses that can contribute to the symptoms of the disease [8,10]. The severity of viral diseases can vary widely, depending on the factors such as the virulence of the virus, the age and health of the host organism, and the method of infection. Some viruses, such as the common cold, cause mild symptoms that are easily managed with over-the-counter medications. Other viruses, such as Ebola or COVID-19, can cause severe illness and death [11].

Virology is also important in the development of vaccines and antiviral treatments. Vaccines stimulate the immune system to produce a specific immune system reaction to a particular virus. This can be done by using an inactivated form of the virus, or by using a fragment of the viral protein coat to stimulate an immune response. Once the immune system has been "primed" to recognize and attack the virus, it can mount a rapid response if the person is exposed to the virus again in the future. Antiviral treatments work by targeting specific aspects of the viral replication cycle. For example, some antiviral drugs interfere with the virus's ability to attach to host cells, while others target the enzymes and other proteins that the virus needs to replicate. Antiviral treatments can be effective in controlling the symptoms of viral infections and reducing the spread of the virus to other people.

In recent years, virology has become even more important due to the emergence of new viral diseases and the potential for pandemics. The COVID-19 pandemic, which began in late 2019 and has since spread around the world, has emphasized the significance of effective public health measures and the rapid development of vaccines and treatments. Virologists have played an important role in the development of these vaccines and treatments, as well as in tracking the spread of the virus and understanding its transmission dynamics.

References

1. Mohamadian M, Chiti H, Shoghli A, Biglari S, Parsamanesh N, et al (2021) COVID�?�19: Virology, biology and novel laboratory diagnosis. J Genet Med 23(2):e3303.

   [Crossref] [Google Scholar] [PubMed]

2. Atri D, Siddiqi HK, Lang JP, Nauffal V, Morrow DA, et al (2020) COVID-19 for the cardiologist: Basic virology, epidemiology, cardiac manifestations, and potential therapeutic strategies. Basic Transl Sci 5(5):518-536.

   [Crossref] [Google Scholar] [PubMed]

3. Oxford JS (2000) Influenza A pandemics of the 20th century with special reference to 1918: Virology, pathology and epidemiology. Rev Med Virol 10(2):119-133. [Google Scholar] [PubMed]
4. Panno S, Matic S, Tiberini A, Caruso AG, Bella P, et al (2020) Loop mediated isothermal amplification: Principles and applications in plant virology. Plants 9(4):461.

   [Crossref] [Google Scholar] [PubMed]

5. Japour AJ, Mayers DL, Johnson VA, Kuritzkes DR, Beckett LA, et al (1993) Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates. The RV-43 study group, the AIDS clinical trials group virology committee resistance working group. Antimicrob Agents Chemother 37(5):1095-101.

   [Crossref] [Google Scholar] [PubMed]

6. Yen-Lieberman B, Brambilla D, Jackson B, Bremer J, Coombs R, et al (1996) Evaluation of a quality assurance program for quantitation of human immunodeficiency virus type 1 RNA in plasma by the AIDS Clinical Trials Group virology laboratories. Clin Microbiol 34(11):2695-2701.

   [Crossref] [Google Scholar] [PubMed]

7. Flint SJ, Racaniello VR, Rall GF, Hatziioannou T, Skalka AM (2020) Principles of virology, Volume 2: Pathogenesis and control. John Wiley & Sons.
8. Luria SE (1953) General virology.

   [Google Scholar]

9. Adams MJ, Antoniw JF, Bar-Joseph M, Brunt AA, Candresse T, et al (2004) Virology Division News: The new plant virus family Flexiviridae and assessment of molecular criteria for species demarcation.  Arc Virol 149:1045-1060.

   [Crossref] [Google Scholar]

10. Pringle CR (1999) Virus taxonomy at the XIth international congress of virology, Sydney, Australia, 1999. Arch Virol 144:2065-2070.

    [Crossref] [Google Scholar] [PubMed]

11. Gerlich WH (2013) Medical virology of hepatitis B: How it began and where we are now. Virol J 10(1):1-25.

    [Crossref] [Google Scholar] [PubMed]