Invasive Rhino-Orbital-Cerebral Mucormycosis in Sinonasal Neuroendocrine Carcinoma- A Case Report

Mucormycosis is an invasive infection due to Mucorale  species with  an acute onset  and have potential to be  life-threatening. Though a relatively uncommon fungal infection in comparison with candidiasis and aspergillosis, mucormycosis cases have been on the rise over the past decade possibly due to the the increased use of chemotherapy, steroids and other immunosuppressants which is associated with prolonged immunocompromised state. Neuroendocrine carcinoma is a rare malignancy of specialised cells called neuroendocrine cells  having both hormone producing as well as nerve cells which  can occur anywhere in the body. Surgical intervention and debridement is the gold standard of treatment for eradicating the infection along with antifungal treatment with Liposomal Amphotericin B formulations and Posaconazole. We report a case of a diabetic women with sinonasal neuroendocrine cancer who developed mucormycosis recovered with  appropriate intravenous antifungal therapy.