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Hindi Research Article, Androl Gynecol Curr Res Vol: 4 Issue: 3
Endometrium Cancer: Evidence of Cooperative Effect of P53 Codon 72 and ACP1 Genetic Polymorphisms on Cancer Grade
| Gloria-Bottini F1*, Nicotra M2, Spina C1, Benedetti-Panici PL2, Neri A1, Magrini A1 and Bottini E1 | |
| 1Department of Biomedicine and Prevention, University of Tor Vergata, Roma, Italy | |
| 2Department of Gynaecologic, Obstetric and Urologic Sciences, University La Sapienza, Roma, Italy | |
| Corresponding author : Fulvia Gloria-Bottini
Department of Biomedicine and Prevention, University of Tor Vergata Via: Montellie-100123 Roma, Italy Tel: +39 06 30889514 E-mail: gloria@med.uniroma2.it |
|
| Received: August 13, 2016 Accepted: September 15, 2016 Published: September 20, 2016 | |
| Citation: Gloria-Bottini F, Nicotra M, Spina C, Benedetti-Panici PL, Neri A, et al. (2016) Endometrium Cancer: Evidence of Cooperative Effect of P53 Codon 72 and ACP1 Genetic Polymorphisms on Cancer Grade. Androl Gynecol: Curr Res 4:2. doi: 10.4172/2327-4360.1000149 |
Abstract
Objective: In the present paper we have searched for a possible cooperative effect of p53 codon 72 and ACP1 genetic polymorphisms on cancer grade. Methods: 69 women with endometrium cancer and 696 adults without cancer have been studied. P53 codon 72 and ACP1 genotypes were determined by DNA analysis. Results: The analysis has shown a cooperative interaction between ACP1 and p53 codon 72 concerning the effect on cancer grade: the proportion of the joint genotype *Arg/*Arg carrying the low activity *A/*A and *A/*B ACP1 genotypes is lower in high grade than in low grade. The proportion of gametic type *A/*Arg is significantly lower in high than in low grade cancer. Conclusion: The combination of the effect of low activity ACP1 that may favor cellular growth with the increase of apoptosis due to *Arg allele could act against the progression towards forms with immature and undifferentiated cells protecting from severe manifestation of cancer.
