Short Communication, J Biochem Physiol Vol: 6 Issue: 2

CD3 Receptor: Bridging Immune Signals for Cellular Harmony

Ruth Orban^*

¹Department of Biology, University of Crete, Crete, Greece

*Corresponding Author: Ruth Orban,
Department of Biology, University of Crete, Crete, Greece
E-mail: orbanruth@uoc.gr

Received date: 29 May, 2023, Manuscript No. JBPY-23-110486;

Editor assigned date: 31 May, 2023, PreQC No. JBPY-23-110486 (PQ);

Reviewed date: 14 June, 2023, QC No. JBPY-23-110486;

Revised date: 21 June, 2023, 2023, Manuscript No. JBPY-23-110486 (R);

Published date: 28 June, 2023 DOI: 10.4172/jbpy.1000136.

Citation: Orban R (2023) CD3 Receptor: Bridging Immune Signals for Cellular Harmony. J Biochem Physiol 6:2.

Abstract

Description

The CD3 receptor, an integral component of the T Cell Receptor (TCR) complex, plays a pivotal role in immune responses by bridging extracellular antigen recognition with intracellular signaling events. It sheds light on the orchestration of immune signals by the CD3 receptor and its crucial role in maintaining cellular harmony [1]. The CD3 receptor is a complex assembly of proteins that reside on the surface of T cells. This intricate arrangement enables the receptor to detect specific antigens, which are molecular signatures found on the surfaces of cells, pathogens, and other foreign entities. Upon binding to a matching antigen, the CD3 receptor initiates a cascade of intricate signalling events that culminate in the activation of the T cell [2]. This activation triggers a wide array of responses, including the proliferation of T cells, the secretion of cytokines, and the targeted destruction of cells recognized as threats..

One of the most fascinating aspects of the CD3 receptor is its adaptability to a remarkably diverse range of antigens. This versatility allows T cells to recognize a multitude of pathogens and abnormal cells, thereby contributing to the immune system's capacity to adapt and respond to new challenges [3]. The receptor's ability to discriminate between "self" and "non-self" is crucial to preventing autoimmune responses where the immune system mistakenly attacks the body's own cells. CD3 receptor doesn't work in isolation. It collaborates with other co-receptors and signalling molecules to finetune immune responses. This collaboration enables the immune system to tailor its reactions based on the context, ensuring that responses are proportionate and targeted [4]. The CD3 receptor stands as a sentinel at the intersection of T cell activation and immune responses. This manuscript aims to unravel the complexities of the CD3 receptor and its critical function in orchestrating immune signals.

Structural organization of the CD3 receptor

TCR complex: The CD3 receptor is a multi-subunit complex closely associated with the TCR.

CD3 subunits: CD3 consists of several subunits (γ, δ, ε, ζ), each contributing to the overall structure and function [5].

ITAM motifs: Immunoreceptor Tyrosine-Based Activation Motifs (ITAMs) within CD3 subunits facilitate signal transduction.

Antigen recognition and T cell activation

TCR-CD3 interaction: The TCR engages antigen-presenting molecules, initiating a cascade of events [6].

CD3-TCR signaling: CD3 receptors amplify and transmit signals upon TCR activation.

Signal integration: CD3 receptor-mediated signals determine T cell fate decisions, proliferation and differentiation.

Intracellular signaling pathways

Tyrosine kinase activation: CD3 receptor activation triggers tyrosine kinase-mediated phosphorylation events [7].

Recruitment of signaling molecules: Phosphorylated ITAMs recruit signaling proteins, such as ZAP-70 and LAT.

Calcium signaling: CD3 activation leads to calcium influx, critical for T cell activation and cytokine production.

CD3 receptor diversity and T cell subsets

TCR affinity and avidity: CD3 receptor characteristics influence TCR binding affinity and T cell response [8].

CD4+ and CD8+ T cells: CD3 receptors play distinct roles in CD4+ helper T cells and CD8+ cytotoxic T cells.

Immunological synapse and cellular communication

Formation of immunological synapse: CD3 receptor clustering facilitates the formation of the immunological synapse between T cells and antigen-presenting cells.

Communication with antigen-presenting cells: The CD3 receptor enables bidirectional signaling between T cells and antigen-presenting cells [9].

Role in autoimmunity and therapeutic interventions

Dysregulation and autoimmunity: Aberrant CD3 receptor signaling contributes to autoimmune diseases.

Therapeutic targeting: Modulating CD3 receptor signaling holds promise for immunotherapy and disease treatment [10].

Future perspectives and challenges

Understanding CD3 dynamics: Studying CD3 receptor dynamics and conformational changes is crucial for a comprehensive view of its function [11].

Personalized immunotherapy: Tailoring therapies based on CD3 receptor characteristics may enhance treatment outcomes.

Conclusion

The CD3 receptor acts as a sentinel, translating extracellular antigen recognition into intracellular signals that orchestrate immune responses. Its diverse roles in cellular communication, activation, and immune regulation underscore its significance in maintaining immune system balance and offer avenues for innovative immunotherapeutic strategies.

References

1. Clevers H, Alarcon B, Wileman T, Terhorst C (1988) The T cell receptor/CD3 complex: a dynamic protein ensemble. Annu Rev Immunol 6(1):629-662.

   [Crossref][Google Scholar][PubMed]

2. Call ME, Wucherpfennig KW (2004) Molecular mechanisms for the assembly of the T cell receptor-CD3 complex. Mol Immunol 40(18 ):1295-1305.

   [Crossref][Google Scholar][PubMed]

3. Ngoenkam J, Schamel WW, Pongcharoen S (2018) Selected signaling proteins recruited to the T‐cell receptor-CD3 complex. J Immunol 153:142-50.

   [Crossref][Google Scholar][PubMed]

4. Minguet S, Swamy M, Alarcón B, Luescher IF, Schamel WW, et al. (2007) Full activation of the T cell receptor requires both clustering and conformational changes at CD3. J Immuni 26(1):43-54.

   [Crossref][Google Scholar][PubMed]

5. Call ME, Pyrdol J, Wiedmann M, Wucherpfennig KW (2002) The organizing principle in the formation of the T cell receptor-CD3 complex. Cell 111(7):967-979.

   [Crossref][Google Scholar][PubMed]

6. Koning F, Lee Maloy W, Coligan JE (1990) The implications of subunit interactions for the structure of the T cell receptor‐CD3 complex. Eur J Immunol 20(2):299-305.

   [Crossref][Google Scholar][PubMed]

7. Wegener AM, Letourneur F, Hoeveler A, Brocker T, Luton F, et al. (1992)  The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell 68(1):83-95.

   [Crossref][Google Scholar][PubMed]

8. Sussman JJ, Bonifacino JS, Lippincott-Schwartz J, Weissman AM, Saito T, Klausner RD et al. (1988) Failure to synthesize the T cell CD3-ζ chain: structure and function of a partial T cell receptor complex. Cell 52(1):85-95.

   [Crossref][Google Scholar][PubMed]

9. Smith CA, Williams GT, Kingston R, Jenkinson EJ, Owen JJ (1989) Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature 337(6203):181-184.

   [Crossref][Google Scholar][PubMed]

10. Blumberg RS, Ley S, Sancho J, Lonberg N, Lacy E, McDermott F, et al. (1990) Structure of the T-cell antigen receptor: Evidence for two CD3 epsilon subunits in the T-cell receptor-CD3 complex. Proc Natl Acad Sci 87(18):7220-7224.

    [Crossref][Google Scholar][PubMed]

11. Soudais C, de Villartay JP, Le Deist F, Fischer A, Lisowska-Grospierre B(1993) Independent mutations of the human CD3–ε gene resulting in a T cell receptor/CD3 complex immunodeficiency. Nat Genet 3(1):77-81.

    [Crossref][Google Scholar][PubMed]