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Hindi Research Article, J Liver Dis Transplant Vol: 3 Issue: 1
A New Pig Model of Auxiliary Partial Liver Transplantation Based on Anastomosis with Intrahepatic Inferior Vena Cava of Recipient
| Bin Chen1, Xiaopeng Chen1*, Yongquan Chen2, Xiaojing Yang1, Linming Lu3, Xiangming Zhu4 and Fangman Chen4 | |
| 1Department of General Surgery, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, 241001, China | |
| 2Anesthesia Department, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, 241001, China | |
| 3Pathology Department, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, 241001, China | |
| 4Medical Image Center, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, 241001, China | |
| Corresponding author : Dr. Xiaopeng Chen Department of Hepatobiliary Surgery, Yijishan Hospital, Wannan Medical College, No 2. , Zheshan West Road, Wuhu, Anhui Province, 241001, China Tel: +86-553-5739626 E-mail: drcxp@qq.com |
|
| Received: January 18, 2014 Accepted: June 16, 2014 Published: June 20, 2014 | |
| Citation: Chen B, Chen X, Chen Y, Yang X, Lu L (2014) A New Pig Model of Auxiliary Partial Liver Transplantation Based on Anastomosis with Intrahepatic Inferior Vena Cava of Recipient. J Liver: Dis Transplant 3:1. doi:10.4172/2325-9612.1000118 |
Abstract
A New Pig Model of Auxiliary Partial Liver Transplantation Based on Anastomosis with
Intrahepatic Inferior Vena Cava of Recipient
Auxiliary partial orthotopic liver transplantation (APOLT) is a feasible approach to treat patients with fulminant hepatic failure and metabolic liver diseases. It is still necessary to establish a simple and reliable APOLT model using large animals for deep research.Ten healthy male or female domestic pigs, weighing 20- 35 kg, were randomly selected to be either donor group (n=8) or recipient group (n=8). The right liver of donor was used as a graft. After the left lobe of recipient was resected, the anterior wall of the distal intrahepatic inferior vena cava was properly dissected. Endto- side anastomosis was performed between graft suprahepatic inferior vena cava and host distal intrahepatic inferior vena cava. End-to-side anastomosis was performed between the donor and recipient portal veins. After the spleen of recipient was resected, end-to-end anastomosis was made between graft hepatic artery and host splenic artery, and a cannula was inserted into host splenicvein for postoperative portal phlebography. The common bile duct of donor was intubated for external drainage.
