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Hindi Research Article, J Food Nutr Disor Vol: 4 Issue: 3
Modelling Kinetics in Intestinal Compartment of Human Body as a Function of Applied Probiotics
| Marijan Bošnjak1*, Zrinka Alfirevi??2, Igor Alfirevi??3 and Ivan Kosalec4 | |
| 1Croatian Academy of Engineering, Ka?i??eva 28,HR-10000 Zagreb, Croatia | |
| 2Croatian Office of Pension Scheme, A. Mihanovi??a 3, HR-10000 Zagreb,Croatia | |
| 3Magdalena Clinical Hospital for Cardio Vascular Diseases, Faculty of Medicine, J. J. Strossmayer University in Osijek, Ljudevita Gaja, 2HR-49217 Krapinske Toplice, Croatia | |
| 4Department of Microbiology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Schrottova 39, HR-10000 Zagreb, Croatia | |
| Corresponding author : Marijan Bošnjak Croatian Academy of Engineering, Kaciceva 28,HR-10000 Zagreb; Home: Slovenska 19, HR-10000 Zagreb, Croatia Tel: 385 1 3722 049 E-mail: marijan.bosnjak@hatz.hr |
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| Received February 11, 2015 Accepted April 09, 2015 Published April 14, 2015 | |
| Citation: Bošnjak M, Alfirevic Z, Alfirevic I, Kosalec I (2015) Modelling Kinetics in Intestinal Compartment of Human Body as a Function of Applied Probiotics. J Food Nutr Disor 4:3. doi:10.4172/2324-9323.1000173 |
Abstract
Modelling Kinetics in Intestinal Compartment of Human Body as a Function of Applied Probiotics
Antibiotic treatments of human body microbial infections are frequently accompanied with a series of side effects which require adequate actions. This work refers to mathematical modelling of process states in a human body appearing during infection, its treatment with antibiotics and consequent application of probiotics. A mathematical model composed of 28 differential equations is being applied to describe a) pharmacokinetics of antibiotic transfer and action, human body viability changes, probiotics transit and changes in intestinal microbiota, b) kinetics of pathogenic microbial infection and infected organism immunity development, and c) intestinal tumor growth kinetics. Computer simulation has been applied to test the adequacy of applied mathematical model. Results of computer simulations expressed graphically and in tables, confirm the model adequacy for explaining process events connected with human body infections and consequent antibiotics and probiotics treatments.
