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Hindi Special Issue Article, Cell Biol Res Ther S Vol: 0 Issue: 0
Mesenchymal Stem Cells: A New Old Tool to Improve Hematopoietic Stem Cell Transplant Outcome
| Nassar A1,2*, Al Bessa M1,3, Abdel Latef N1,4 and El Sayed N1,3 | |
| 1King Abdullah medical city, Mekka, Saudi Arabia | |
| 2National research center, Cairo, Egypt | |
| 3University of Alexandria, Alexandria, Egypt | |
| 4National cancer institute, Cairo, Egypt | |
| Corresponding author : Amr Nassar, MD King Abdullah Medical City, Al Mashaeer District, Mekka 57657, Saudi Arabia Tel: 00966599375199/ 0096625549999; Fax:0096625532239-80149 E-mail: amrnassar5@gmail.com |
|
| Received: July 01, 2013 Accepted: November 23, 2013 Published: November 27, 2013 | |
| Citation: Nassar A, Bessa MA, Latef NA, El Sayed N (2014) Mesenchymal Stem Cells: A New Old Tool to Improve Hematopoietic Stem Cell Transplant Outcome. Cell Biol: Res Ther S1:005 doi:10.4172/2324-9293.S1-005 |
Abstract
Mesenchymal Stem Cells: A New Old Tool to Improve Hematopoietic Stem Cell Transplant Outcome
Mesenchymal stem cells (MSCs) are a subpopulation of multipotent stem cells that exhibit a capacity to support hematopoiesis, play an immunomodulatory function and differentiate into different mesodermal tissues helping tissue repair. MSCs can be isolated and ex-vivo expanded from different tissues. Co-infusion of MSCs with hematopoietic stem cells (HSC) might have a positive effect on engraftment and graft versus host disease (GVHD) prophylaxis and management. However, the technique used for isolation and exvivo expansion needs to be both optimized as well as standardized to ensure the best outcome. In this review we will try to revise the clinical experience with collecting, expanding and utilizing MSCs in the setup of hematopoietic stem cell transplant (HSCT).
