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Hindi Editorial, J Immunodefic Disor Vol: 2 Issue: 1
Mast Cells as Reservoirs for HIV Latency
| Silvia Bulfone-Paus1,2* | |
| 1Faculty of Human and Medical Sciences, University of Manchester, M13 9PT, UK | |
| 2Department of Immunology and Cell Biology, Research Centre Borstel, 23845 Borstel, Germany | |
| Corresponding author : Silvia Bulfone-Paus Faculty of Human and Medical Sciences, University of Manchester, M13 9PT, UK and Department of Immunology and Cell Biology, Research Centre Borstel, 23845 Borstel, Germany E-mail: silvia.bulfone-paus@manchester.ac.uk |
|
| Received: October 17, 2012 Accepted: October 18, 2012 Published: October 22, 2012 doi:10.4172/2324-853X.1000e108 | |
| Citation: Getachew A. Dagne (2012) Methods for Analyzing Immunodeficiency Data with a Lower Limit of Quantification . J Immunodefic Disor 1:2. doi:10.4172/2324-853X.1000e108 |
Abstract
Mast Cells as Reservoirs for HIV Latency
More than a decade ago, Bannert and colleagues first reported that human mast cell (MC) progenitors are susceptible to infection with HIV-1. This finding was confirmed and extended by other groups in the following years providing in vivo evidence that tissue MCs, developing from infected human MC progenitors, remain productively infected in infected people. Moreover, evidence was shown that Toll-like receptor (TLR) 2, TLR4, or TLR9 stimulation of latently infected mast cells induced re-initiation of HIV-1 replication.