The liver supports almost every organ in the body. Liver is prone to several diseases due to its strategic location and multidimensional functions. The liver is the largest glandular organ in the body and performs many vital functions to keep the body pure of toxins and harmful substances. Cell Biology, in simple is the study of Cells. The cell is the basic structural, functional and biological unit of all known living organisms and also known as building blocks of Life. Hence Cell biology is the fundamental science for all the related branches knowing the cell mechanism. The liver is made up of numerous lobules which are packed with virtually identical cells called liver cells or hepatocytes. The various functions of the liver are carried out by the Hepatocytes. This branch deals with the role of Hepatocytes and gains a greater understanding of basic biological functions of hepatic cells such as protein/lipid traffic, cytoskeletal organization, cellular polarity, and receptor signaling cascades in health and disease. Also Pathological changes in cellular functions can translate into modulation of trafficking, cell adhesion and matrix production leading to liver damage, cholestasis, and fibrogenic signals. Understand how the central processes listed above are altered and tailored to suit the highly specialized functions of the liver including regeneration, bile formation, endocytic-based filtering of the blood, secretion of essential plasma proteins, and regulation of the extracellular matrix. On the whole, cell biology focuses on the structure and function of a cell, from the most general properties shared by all cells, to the unique, highly intricate functions particular to specialized cells.