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Hindi Research Article, J Pharm Drug Deliv Res Vol: 3 Issue: 2
Inhibiting Human Lactate Dehydrogenase-C for Male Fertility Control; Initial Hits
| Ranjna C Dutta1*, Nitin W. Fadnavis 2 and Erwin Goldberg1 |
| 1Biochemistry Molecular Biology and Cell Biology, Northwestern University, Evanston, IL-60208, USA |
| 2Discovery Lab, Indian Institute of Chemical Technology, Hyderabad, India |
| Corresponding author : Ranjna C Dutta 12-5-149/16-2, Vijayapuri, South Lalaguda, Hyderabd-500017, AP, India Tel:91-40-27007288 Email: ranjna_dutta@rediffmail.com |
| Received: March 18, 2014 Accepted: July 25, 2014 Published: October 2, 2014 |
| Citation: Ranjna CD, Nitin WF, Erwin G (2014) Inhibiting Human Lactate Dehydrogenase-C for Male Fertility Control; Initial Hits. J Pharm Drug Deliv Res 3:2. doi:10.4172/2325-9604.1000125 |
Abstract
Lactate dehydrogenase-C (LDH-C) is an oxido-reductive enzyme of LDH (EC 1.1.1.27) family which is present abundantly in testes, spermatocytes, spermatids and sperms. It plays an important role in maintaining glycolysis and ATP production in the flagellum during sperm capacitation, therefore essential for male fertility. Profuse expression exclusively in these tissues makes LDH-C a potential target for male contraceptive development. However, creating a specific inhibitor for LDH-C is challenging due to its extensive sequence similarity (84-89%) with somatic isozymes LDH-A and B.
