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Hindi Research Article, J Forensic Toxicol Pharmacol Vol: 3 Issue: 1
Influence of Aeromonas hdrophilia Infection on the Disposition Kinetic of Norfloxacin in Goldfish (Carassius auratus auratus)
| Mohamed Aboubakr1*, Abdelazem Mohamed Abdelazem1 and Ashraf Mohamed Abdellatif2 | |
| 1Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736, Moshtohor, Toukh, Qaliobiya, Egypt | |
| 2Department of Fish Diseases and Management, Faculty of Veterinary Medicine, Benha University, 13736, Moshtohor, Toukh, Qaliobiya, Egypt | |
| Corresponding author : Dr. Mohamed Aboubakr Department of pharmacology, Faculty of Veterinary Medicine, Benha University, 13736, Moshtohor, Toukh, Qaliobiya, Egypt Tel: +201099874671; Fax: +20132463074 E-mail: mohamedhafez19@yahoo.com; mohamed.aboubakr@fvtm.bu.edu.eg |
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| Received: November 28, 2013 Accepted: March 11, 2014 Published: March 18, 2014 | |
| Citation: Aboubakr M, Abdelazem AM, Abdellatif A (2014) Influence of Aeromonas hdrophilia Infection on the Disposition Kinetic of Norfloxacin in Goldfish (Carassuys auratus Linnaeus). J Forensic Toxicol Pharmacol 3:1. doi:10.4172/2325-9841.1000115 |
Abstract
Influence of Aeromonas hdrophilia Infection on the Disposition Kinetic of Norfloxacin in Goldfish (Carassius auratus)
The pharmacokinetic of norfloxacin (10 mg kg-1) following single intravenous (IV) and oral administration (PO) in healthy goldfish were investigated. Also, repeated (PO) administration of norfloxacin in healthy and experimentally Aeromonas hydrophilia infected goldfish was studied. Following IV administration, norfloxacin obeyed a two compartments open model, distribution half-life (t1/2(α)) equal to 0.12 h, volume of distribution (Vdss) was 1.01 L kg-1, elimination halflife (t1/2(β)) was 4.30 h and total body clearance (CLtot) was 0.17 L kg-1h-1. Following PO administration, norfloxacin was rapidly and efficiently absorbed through gastrointestinal tract as the absorption half-life (t1/2(ab)) was 0.84 h.
