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Hindi Research Article, J Nanomater Mol Nanotechnol Vol: 2 Issue: 6
In Vivo Biocompatibility Evaluation of Gelatin�Hydroxyapatite Crosslink Biomimetic Scaffolds for Bone Regeneration
| Sorasun Rungsiyanont1*, Kanako Noritake2, Warunee Pluemsakunthai2, Somchai Yodsanga3, Somporn Swasdison3 and Shohei Kasugai2 |
| 1Associate professor, Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, Srinakharinwirot University, Thailand |
| 2Department of Implantology,Graduation School of Tokyo Medical and Dental University, Tokyo, Japan |
| 3Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, Pathumwan 10330, Thailand |
| Corresponding author : Dr. Sorasun Rungsiyanont Associate professor, Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, Srinakharinwirot University, Wattana, Bangkok 10110, Thailand Tel/Fax: 662-6641882 E-mail: peted2000@hotmail.com |
| Received: August 15, 2013 Accepted: October 16, 2013 Published: October 20, 2013 |
| Citation: Rungsiyanont S, Noritake K, Pluemsakunthai W, Yodsanga S, Swasdison S, et al. (2013) In Vivo Biocompatibility Evaluation of Gelatin–Hydroxyapatite Crosslink Biomimetic Scaffolds for Bone Regeneration. J Nanomater Mol Nanotechnol 2:6. doi:10.4172/2324-8777.1000126 |
Abstract
In Vivo Biocompatibility Evaluation of Gelatin–Hydroxyapatite Crosslink Biomimetic Scaffolds for Bone Regeneration
Biomimetic gelatin (gel)/hydroxyapatite (HA) scaffolds have been prepared for bone regeneration and hard tissue engineering. (A) 2.5% gel solely and (B) coprecipitation of 2.5% gel with 2.5% HA (w/w) were prepared to evaluate their biocompatibility, biodegradation and defect shape maintenance for regeneration. Sixteen week-old Vista rats (n=30) were used and calvarial defects were grafted with these scaffolds.
